The Munich researchers can find the Marker in the blood, the heavy Covid-19-history predicts

Doctors of the Munich LMU hospital were able to demonstrate in a pilot study, that in patients with severe Covid-19-gradients of a certain chemical messenger in the blood is increased. He could help in the future, severe courses of the disease to detect at an early stage.

Covid-19 can take for the patient a very different course. For physicians, it is therefore helpful early on, what is the Corona-patients, respiratory failure is imminent. These patients could then be monitored intensively. Patients without the risk characteristics could be treated in return, on the normal station or even at home, courts in intensive care units protected and those to be assigned to the you really need.

As the disease progresses, is yet to be, however, difficult to predict. Doctors of the LMU hospital, Munich now want to have a so-called biomarkers found to accurately make this distinction. Their results were published in the “Journal of Allergy and Clinical Immunology”.

“Predicted the later of lung failure with a high degree of accuracy”

For their study, Tobias Herold and Tobias Weinberger, senior physicians of Central emergency Department (ZNA) studied at the Campus Großhadern of the LMU hospital, the clinical course and laboratory parameters of 89 Covid-19-patients had to be treated due to the Severity of their disease in the hospital. 32 of them – mostly men – had to be at least in the meantime, use a respirator in the hospital.

In the analysis of patient data revealed that they all had elevated levels of a Marker for inflammation – and the messenger substance, Interleukin-6, and briefly IL-6.

Even more: “An IL-6 value of more than 80 picogram/Milliliter, and a CRP value of more than 9.7 milligrams/deciliter during the disease and later lung ahead of failure with a high degree of accuracy said,” write the attendings. The risk of pulmonary failure was increased for patients with elevated values many times over.

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Further studies are needed

Thus, while it was previously unclear whether the messenger is a key factor of the escalating disease process in the lung, or merely a Marker of disease activity, limit the physicians. If the former is true but, could drugs that intervene in these inflammatory processes influence the disease course in the future.

To address this question, am currently also carried out at the LMU clinic for a follow-up study. This attempts to limit the excessive inflammatory process.

“Need a Marker, the clinical course predictions”

Most people become ill after infection with the Virus Sars-CoV-2 only slightly and recover quickly, the hospital. In about five percent of the patients, but there is a severe Disease process with respiratory distress. Some of these patients should be ventilated on the intensive care artificial. To identify at an early stage was particularly important to the demand for beds in the clinics to assess.

“We saw in March and April, many patients with Covid-19 decide in our emergency room and had to anticipate which of the patients with a severe course of the disease is,” explained the Munich-based senior physicians. In order to identify patients for whom a deterioration of the state threatens, “we need markers to tell the clinical course of this previously”.

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