<img class="aligncenter" src="https://scx1.b-cdn.net/csz/news/800a/2023/normalizing-tumor-bloo.jpg"
alt="Normalizing tumor blood vessels may improve immunotherapy against brain cancer"
title="Anti-VEGF treatment improves the efficacy of EGFRvIII-CAR-T cells in murine GBM tumor models. (A) Schematic representation of experimental setup to evaluate the effect of PBS, CAR-T, B20, IgG+CAR T and B20+CAR T on the survival of GSC005 and C2TA GBM-bearing mice. (B) and (C) Tumor growth kinetics and median survival for CT2A tumors (PBS (n=22, 15.5 days), CAR-T (n=14, 20.5 days), B20 (n=8, 24.5 days), B20+CAR T (n=19, l lysine and zovirax 32 days)). (D) and (E) Tumor growth kinetics and median survival for GSC005 tumors (PBS (n=12, 13.5 days), CAR-T (n=17, 18.5 days), B20 (n=10, 24 days), IgG+CAR T (n=13, 18 days), B20+CAR T (n=21, 37 days)). Error bars show median±SEM. Statistical analysis was performed using Student’s t-test or one-way ANOVA test. *p Journal for ImmunoTherapy of Cancer (2023). DOI: 10.1136/jitc-2022-005583″ width=”800″ height=”530″>
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