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New knowledge about airborne virus particles could help hospitals

The risk of being exposed to COVID-19 particles increases with shorter physical distance to a patient, higher patient viral load and poor ventilation. Measurements taken by researchers at Lund University in Sweden of airborne virus in hospitals provide new knowledge about how best to adapt health care to reduce the risk of spread of infection. Researchers hope current international guidelines in health care will be changed.

At the beginning of the COVID-19 pandemic, it was believed that infection was primarily spread via large droplets from people with symptoms of disease. Over time, it became clear that people are most infectious at the onset of disease and inhaling airborne virus proved to be an important route of transmission. Most guidelines only included the risk of aerosol infection in certain health care situations, for example when respiratory support was provided. Although many of the work methods have been developed over the course of the pandemic, the guidelines used to assess the risk of infection in health care have been based on outdated knowledge.

“We have now confirmed what we have learnt during the pandemic, that what affects the risk of spread of infection is how much virus the patient is transmitting, the physical distance to the patient and the quality of the ventilation in the room. However, sintomas de la synthroid it does not seem that respiratory support affects the risk of virus in the air. As a result, we hope that the WHO recommendations will be changed and health care procedures adapted,” says Carl-Johan Fraenkel, consultant and specialist in infection medicine and infection control at SUS, and researcher at Lund University.

From spring 2020 to spring 2021, researchers at Lund University took many measurements in hospital environments, primarily at different COVID-19 wards at Skåne University Hospital in Lund and Malmö, with the aim to obtain more knowledge about how COVID-19 is spread. The study is the largest of its kind and the results have now been published in the scientific journal Clinical Infectious Diseases.

Measurements of virus in the air were taken in the rooms of intensive care patients as well as in other wards. One important factor in the measurements is that hospitalized patients had generally been infected for one to two weeks before they became so ill that they required care, meaning that their viral load was not as high as that of patients with recent infections.

The measurements were taken with instruments that are custom-made to collect biological substances from the air, and samples were collected from corridors and communal spaces as well as inside patient rooms. In total, 310 samples were collected, of which 231 were collected in patient rooms. In total, eight percent of all the samples were positive, and the figure for samples taken from patient rooms was ten percent. The reason for the relatively low number is precisely because the patients had been sick for so long, meaning they were not transmitting as much of the virus into the air.

“We collected many samples in different patient situations and measured how many virus particles there were in the collected air samples. We then linked these to the viral load the patient had in their body, what the ventilation was like inside the room and the distance to the patient,” explains Sara Thuresson, doctoral student in aerosol technology at Lund University.

With these measurements, researchers were able to establish that improved ventilation, both with mobile HEPA-filtration units and with higher installed ventilation rates, clearly reduces the risk of airborne virus.

“We also collected samples from different distances: less than one meter from the patient, one to two meters away and more than two meters away. The risk of infection increases by 50 percent for each category as you get closer to the patient,” says Sara Thuresson.

It has now been established that COVID-19 is primarily transmitted via fine aerosol particles containing the virus. These can remain in the air for many minutes and spread further than two meters, particularly in poorly ventilated environments. The particles can also get through the gaps in surgical masks or respirators. Despite this, many infection control programs are based on previous notions about the spread of infection.

As current guidelines have been followed, health care staff have primarily used the best personal protective equipment when treating the sickest patients, those on ventilators or receiving other respiratory support.

“However, this patient group seems to be the least infectious, instead, it is the newly infected patients in other wards who are the most infectious, and with whom more basic protective equipment has been used,” says Carl-Johan Fraenkel.

Further research is underway on how significant the risk of infection is in waiting rooms and corridors, where it is more common to find patients or staff without any symptoms but who may also be carrying infectious virus.

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