New anti viral inhibits SARS-CoV-2, and other corona viruses
There is new hope for an active ingredient against the Coronavirus SARS-CoV-2 induced lung disease COVID-19: An American research team presented an anti-viral broadband active ingredient that is effective against several coronaviruses, including SARS-CoV-2, SARS-1 and MERS.
Researchers at the American Association for the Advancement of Science, published study results in which a new broad-band anti viral against corona virus will be presented. The active substances neutralised the corona virus in human airway cells were collected from COVID-19-Concerned. In addition, the chances of Survival in infected mice improved by Compounds. The results of the research were recently presented in the prestigious scientific journal “Science Translational Medicine”.
Effective treatments against coronaviruses are missing
Pathogenic corona virus represents a global threat to public health, such as the corona virus, SARS-1, MERS, and the current SARS-CoV-2 clearly demonstrate. Currently there are few effective drugs and no approved vaccines. The Team of the current study presents a new hope in the fight against corona viruses.
Drug group inhibits the multiplication of viruses
The researchers to I Rathnayake studied anti-viral Compounds, which are referred to as the 3C-like protease inhibitors (3CLpro). These molecules inhibit certain enzymes, resulting in the degradation of certain proteins is prevented. The enzymes that are inhibited by the inhibitors, are essential for the propagation of viruses.
Two active substances were against corona virus effectively
Among the tested Compounds, two compounds showed a strong activity against SARS-CoV-2. The substance with the name 6e made in human cells that the virus could be ten times slower to multiply. Another potent active ingredient called 6j increased the chances of Survival of mice infected with the MERS-Virus – a close relative of SARS-CoV-2. The compound decreased the amount of virus in the lungs of the mice and prevented dangerous complications such as pulmonary edema.
The research team sees great potential in the discovered Connections and wants to develop an anti-viral broadband-a drug against corona viruses. (vb)
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