What is Folic Acid?

Folic acid is a part of the B complex of vitamins. It is vital for red blood cells and for many other cells in the body. The form of folic acid occurring naturally in food is called ‘folate’.

Functions of folic acid

Folic acid, along with vitamin B12, is important for formation of red blood cells. Lack of these two vital nutrients leads to variety of anemia called macrocytic anemia. This means the red blood cells appear bloated and large and have a reduced capacity to carry oxygen.

Folate along with other B vitamins are also vital for nerve function. Folate is essential for the formation of DNA (genetic material) within every body cell. This allows normal replication of cells.

Biochemically folates act as chemicals that medicate one-carbon transfer reactions. These are important for formation of purines and pyrimidines. These purines and pyrimidines form basic building blocks for DNA.

Folate requirements

Most of the required folate in men and non-pregnant women are obtained from a healthy and well-balanced diet. Pregnant and breast feeding women and children during their growing years require folate in their diet. In pregnant women, for example, lack of folate in diet can lead to severe nerve defects like neural tube defects, spina bifida, anencephaly etc. in their unborn children.

Daily recommendations for folate (folic acid)

• Adults and children over 11 years: 200μg

• Any woman considering pregnancy: 200μg plus a folate supplement containing 400μg

• Pregnant Women: 300μg plus a 400μg supplement during the first 12 weeks of pregnancy
• Breast feeding women – 260μg

Folate deficiency

Folate deficiency occurs in two cases – excess demands of folate (e.g. during pregnancy and breast feeding) and excessive loss (e.g. Crohns disease or untreated coeliacdisease, alcoholism, use of medications like diuretics etc.).

Symptoms of folate deficiency

In cases of folate deficiency there may be some general symptoms of anemia like fatigue and tiredness. There may be features of diarrhoea, loss of appetite, weight loss, headaches, heart palpitations, sore tongue and behavioural disorders.

Folate deficiency during pregnancy

During pregnancy folate deficiency is associated with nerve defects in the fetus. The fetus develops rapidly and develops spine and nerve cells in the first few weeks of pregnancy. Inadequate blood levels of folate during this time increase the risk of the baby’s spine developing a ‘neural tube defect’. This may cause spinal malformation called spina bifida.

Folates also help in reduction of high levels of homocysteine. Homocysteine is a protein that irritates blood vessels. This leads to increased risk of heart attack or stroke.

Foods rich in folic acid

Folate is found naturally in dark green leafy vegetables. The word folate in fact comes from the word foliage. Folate is a water-soluble vitamin and is thus lost easily from vegetables during cooking. This can be prevented by avoiding over-cooking. Folate can also be preserved by steaming ormicrowaving vegetables rather than boiling them in open.

Folates are also present in foods fortified with folic acid. This is practiced in many countries since, despite recommendations, many women do not take folic acid supplements in early pregnancy. Foods commonly fortified with folic acid are breakfast cereals, flour etc.

Over dosage of folate in diet and as supplements

Routine fortifications may not be beneficial as folates need to be supplemented along with vitamin B 12 because if not administered together a vitamin B12 deficiency mediated nerve damage may be unmasked and this may lead to irreversible nerve damage. Elderly are most at risk as uptake of vitamin B12 from diet reduces with age.

Those over 50 are advised not to take folic acid supplements containing more than 200μg/day. For others, long-term intakes of folic acid from fortified foods and supplements should be below 1mg/day for adults (lower amounts for children).

Further Reading

• All Folic Acid Content
• Folic Acid and Health
• Folic Acid Biology
• Folic Acid Supplementation
• Food High in Folic Acid

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.